Doug Berger, psychiatrist in Tokyo comments on: “Antidepressants in Pregnancy: Balancing Needs and Risks in Clinical Practice”,

Psychiatric Times, April 29, 2017

By Lauren M. Osborne, MD, Katherine McEvoy, MB ChB, and Jennifer L. Payne, MD

Original Article’s URL:

Dear authors, you mention that psychotherapy, yoga, acupuncture are “evidence-based nonpharmacological treatments” for mood disorders during pregnancy. I wonder if you can reference any study of these 3 modalities that had a double-blind placebo control that I’m sure you would agree is necessary if you study an indication with subjective endpoints like a mood disorder? If you cannot (not just rater blind or randomized), and I know you cannot, I would temper the word evidence-based.

On Acupuncture, here is a recent article:

Research Casts Doubt on the Value of Acupuncture, Scientific studies show that the procedure is full of holes, Scientific American, August 2016

The article makes these statements below:

1. Effects of acupuncture are the same whether needles are placed along the meridians or at random locations around the body.

2. Acupuncture studies are extremely difficult to double-blind—a methodological approach in which neither the researchers nor patients know who is receiving the treatment under investigation and who is receiving the placebo or sham.

3. Researchers know which patients receive or do not receive real acupuncture, likely biasing the results.

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